Publications and Patents
PUBLICATIONS
2024
“DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs” Hironori Saito, Yuma Handa, Mingming Chen, Tilman Schneider-Poetsch, Yuichi Shichino, Mari Takahashi, Daniel Romo, Minoru Yoshida, Alois Fürstner, Takuhiro Ito, Kaori Fukuzawa, Shintaro Iwasaki Nat. Commun. 2024, 15, 7418. Link
“Antioxidant, anti-tyrosinase, hepatoprotective, and anti-inflammatory potential in flowers and seeds of Ochna integerrima (Lour.) Merr” Hien Minh Nguyen*, Khanh Phuc Nguyen, An Thuy Pham Le, Nguyen Huong Thi Nguyen, Long Kim Vu-Huynh, Chi Kim Thi Le, Anjana Delpe Acharige, Kenneth Hull and Daniel Romo* Nat. Prod. Res. 2024, 1-11. Link.
“Dopamine-Derived Guanidine Alkaloids from a Didemnidae Tunicate: Isolation, Synthesis, and Biological Activities” Ryuichi Sakai,* Ken Matsumura, Hajime Uchimasu, Kei Miyako, Tohru Taniguchi, V. Raghavendra Rao Kovvuri, Anjana Delpe Acharige, Kenneth G. Hull, Daniel Romo,* Lakkana Thaveepornkul, Sarin Chimnaronk,* Hiroko Miyamoto, Ayato Takada, Hiromi Watari, Masaki J. Fujita, and Jiro Sakaue J. Org. Chem. 2024, 89, 5977-5987. Link
“Transient Receptor Potential Melastatin 7 (TRPM7) Ion Channel Inhibitors: Preliminary SAR and Conformational Studies of Xenicane Diterpenoids from the Hawaiian Soft Coral Sarcothelia edmondsoni” Guangmin Yao, Matthew R. Parris, W. Cedric Kuo, Peter Pörzgen, Brandi Castillo, Evan S. Mason, Andres Chinchilla, Junhao Huang, Sayuri Suzuki, Rylee Ross, Ellis Akana, Savana Vander Schuit, Steven P. Miller, Reinhold Penner, Hong-Shuo Sun, Zhong-Ping Feng, Kenneth G. Hull, Daniel Romo,* Andrea Fleig,* and F. David Horgen* J. Nat. Prod. 2024, 87, 783-797. Link
2023
“Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1” Kim Joana Westerich, Katsiaryna Tarbashevich, Jan Schick, Antra Gupta, Mingzhao Zhu, Kenneth Hull, Daniel Romo, Dagmar Zeuschner, Mohammad Goudarzi, Theresa Gross-Thebing and Erez Raz Developmental Cell 2023, 58, 1–15. Link
2021
“Second-Shell Amino Acid R266 Helps Determine N‑Succinylamino Acid Racemase Reaction Specificity in Promiscuous N‑Succinylamino Acid Racemase/o‑Succinylbenzoate Synthase Enzymes” Dat P. Truong, Simon Rousseau, Benjamin W. Machala, Jamison P. Huddleston, Mingzhao Zhu, Kenneth G. Hull, Daniel Romo, Frank M. Raushel, James C. Sacchettini, and Margaret E. Glasner Biochemistry 2021, 60, 3829-3840. Link
“Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A” Sai Kiran Naineni, Jason Liang, Kenneth Hull, Regina Cencic, Mingzhao Zhu, Peter Northcote, Paul Teesdale-Spittle, Daniel Romo, Bhushan Nagar and Jerry Pelletier Cell Chem. Bio. 2021, 28, 1-10. Link
2020
“Waixenicin A, a marine-derived TRPM7 inhibitor: a promising CNS drug lead” Hong-Shuo Sun, F. David Horgen, Daniel Romo, Kenneth G. Hull, Sigrid A. Kiledal, Andrea Fleig and Zhong-Ping Feng Acta Pharmacol. Sin. 2020, 41, 1519-1524. Link
“Synthetic Tigliane Intermediates Engage Thiols to Induce Potent Cell Line Selective Anti-Cancer Activity” Sharon Chow, Tanja Krainz, Christian J. Bettencourt, Natasa Broit, Blake Ferguson, Mingzhao Zhu, Kenneth G. Hull, Gregory K. Pierens, Paul V. Bernhardt, Peter G. Parsons, Daniel Romo, Glen M. Boyle and Craig M. Williams Chem. Eur. J. 2020, 26, 13372-13377. Link
“Antiproliferative activity of naphthoquinones and indane carboxylic acids from lapachol against a panel of human cancer cell lines” Kenneth O. Eyong, Herve L. Ketsemen, Zhenze Zhao, Liqin Du, Aude Ingels, Veronique Mathieu, Alexander Kornienko, Kenneth G. Hull, Gabriel N. Folefoc, Sundarababu Baskaran, Daniel Romo Med. Chem. Res. 2020, 29, 1058-1066. Link
“Molecular Mechanism for Attractant Signaling to DHMA by E. coli Tsr” Asuka A. Orr, Jingyun Yang, Nitesh Sule, Ravi Chawla, Kenneth G. Hull, Mingzhao Zhu, Daniel Romo, Pushkar P. Lele, Arul Jayaraman, Michael D. Manson, and Phanourios Tamamis Biophysical Journal 2020, 118(2), 492-504. Link
2019
“Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia” Rong Chen, Mingzhao Zhu, Rajan R. Chaudhari, Omar Robles, Yuling Chen, Wesley Skillern, Qun Qin, William Wierda, Shuxing Zhang, Kenneth G. Hull, Daniel Romo, William Plunkett Leukemia 2019, 33, 1663–1674 link
“A Novel Actin Binding Drug with In Vivo Efficacy” , , , , , , , , , , ,
2018
“Comparison of Alicyclobacillus acidocaldarius o‑Succinylbenzoate Synthase to Its Promiscuous N‑Succinylamino Acid Racemase/o‑Succinylbenzoate Synthase Relatives” Denis Odokonyero, Andrew W. McMillan, Udupi A. Ramagopal, Rafael Toro, Dat P. Truong, Mingzhao Zhu, Mariana S. Lopez, Belema Somiari, Meghann Herman, Asma Aziz, Jeffrey B. Bonanno, Kenneth G. Hull, Stephen K. Burley, Daniel Romo, Steven C. Almo, and Margaret E. Glasner Biochemistry 2018, 57(26), 3676-3689. Link: https://pubs.acs.org/doi/full/10.1021/acs.biochem.8b00088
“Triterpenoids from the stem bark of Vitellaria paradoxa (Sapotaceae) and derived esters exhibit cytotoxicity against a breast cancer cell line” Kenneth O. Eyong, Guerisson Baïrys, Anna A. Eno, Joseph Taube, Kenneth G. Hull, Gabriel N. Folefoc, Harquin S. Foyet, and Daniel Romo Med. Chem. Res. 2018, 27, 268-277. Link: https://doi.org/10.1007/s00044-017-2059-7
2017
“Bioactive Seco-Lanostane-Type Triterpenoids from the Root of Leplaea mayombensis” Lazare S. Sidjui, Kenneth O. Eyong, Kenneth G. Hull, Gabriel N. Folefoc, Valerie M. Leddet, Gaёtan Herbette, Evelyne Ollivier, Joseph Taube, Kevin Klausmeyer, and Daniel Romo J. Nat. Prod. 2017, 80, 2644-2651. Link: http://pubs.acs.org/doi/full/10.1021/acs.jnatprod.7b00210
“A Strategy for Dual Inhibition of the Proteasome and Fatty Acid Synthase with Belactosin C-Orlistat Hybrids” Mingzhao Zhu, Wayne D. Harshbarger, Omar Robles, Joanna Krysiak, Kenneth G. Hull, Sung Wook Cho, Robyn D. Richardson, Yanyan Yang, Andres Garcia, Lindsey Spiegelman, Bianca Ramirez, Christopher T. Wilson, Ju Anne Yau, James T. Moore, Caitlen B. Walker, James C. Sacchettini, Wenshe R. Liu, Stephan A. Sieber, Jeffrey W. Smith and Daniel Romo Bioorg. Med. Chem. 2017, 25, 2901-2916. Link: http://dx.doi.org/10.1016/j.bmc.2017.01.020
2016
“HSV-2 Virion Host Shutoff Endoribonuclease Activity is Required to Disrupt Stress Granule Formation” Renee Finnen, Mingzhao Zhu, Jing Li, Daniel Romo, and Bruce Banfield J. Virol., 2016, 90, 7943-7955. Link: 10.1128/jvi.00947-16
“Chemical Mechanism of the Phosphotriesterase from Sphingobium sp. Strain TCM1, an Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants” Andrew N. Bigley, Dao Feng Xiang, Zhongjie Ren, Haoran Xue, Kenneth G. Hull, Daniel Romo, Frank M. Raushel J. Am. Chem. Soc. 2016, 138, 2921-4. Link
2015
“Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-induced Platelet Reactivity Independent of Reactive Oxygen Species” Hengjie Yuan; Katie Houck; Ye Tian; Uddalak Bharadwaj; Ken Hull; Zhou Zhou; Mingzhao Zhu; Xiaoping Wu; David Tweardy; Daniel Romo; Xiaoyun Fu; Yanjun Zhang; Jianning Zhang; Jing-fei Dong PLOS ONE 2015 10(12): December 8, 2015 DOI: 10.1371/journal.pone.0146626. Link
“Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers” Dao Feng Xiang, Andrew N. Bigley, Zhongjie Ren, Haoran Xue, Kenneth G. Hull, Daniel Romo, Frank M. Raushel Biochemistry 2015, 54, 7539–7549. Link
2014
“Role of an Active Site Loop in the Promiscuous Activities of Amycolatopsis sp. T-1-60 NSAR/OSBS” Andrew W. McMillan, Mariana S. Lopez, Mingzhao Zhu, Benjamin C. Morse, In-cheol Yeo, Jaleesia Amos, Ken Hull, Daniel Romo, Margaret E. Glasner Biochemistry 2014, 53, 4434-4444. Link
“Promiscuity of Exiguobacterium sp. AT1b o-Succinylbenzoate Synthase Illustrates Evolutionary Transitions in the OSBS Family” Ashley M. Brizendine, Denis Odokonyero, Andrew W. McMillan, Mingzhao Zhu, Ken Hull, Daniel Romo and Margaret E. Glasner Biochem. Biophys. Res. Commun. 2014,450, 679-684. Link
“Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents” Woon-Kai Low, Jing Li, Mingzhao Zhu, Sai Shilpa Kommaraju, Janki Shah-Mittal, Ken Hull, Jun O. Liu, Daniel Romo Bioorg. Med. Chem. 2014, 22, 116-125. Link
2013
“Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification” Pingzhu Zhou, Yijing Zhang, Qing Ma, Fei Gu, Daniel S. Day, Aibin He, Bin Zhou, Jing Li, Sean Stevens, Daniel Romo, Peter J. Park, and William T. Pu Proc. Natl. Acad. Sci., 2013, 110, 15395-15400. Link
2012
“Simultaneous Arming and Structure-Activity Relationship Studies of Natural Products via C- and N-Amination: Cellular Targets of Eupalmerin Acetate” Jing Li, Justin S. Cisar, Congying Zhou, Brunilda Vera, Howard Williams, Abimael D. Rodríguez, Benjamin F. Cravatt, Daniel Romo Nat. Chem. 2012, 5, 510-517. Link
2011
“A Chemifluorescent Immunoassay for the Determination of Marinobufagenin in Body Fluids”, Abi-Ghanem, D.; Lai, X.Z.; Berghman, L.C.; Horvat, D.; Li, J.; Romo, D.; Uddin, M.N.; Kamano, Y.; Nogawa, T.; Xu, J.P.; Pettit, G.R.; Puschett, J.B. J. Immunoassay Immunochem. 2011, 32, 31-46. Link
“Marinobufagenin Levels in Preeclamptic Patients: A Preliminary Report” Enoch Agunanne, Darijana Horvat, Recherael Harrison, M. Nasir Uddin, Richard Jones, Thomas J. Kuehl, Daad Abi Ghanem, Luc R. Berghman, Xinzhong Lai, Jing Li, Daniel Romo, Jules B. Puschett American Journal of Perinatology 2011, 28, 509-514. Link
2010
“Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite differentiation, roliferation, and viability” Yau W-K.; Blisnick, T.; Taly J.-F.; Helmer-Citterich, M.; Schiene-Fischer, C.; Leclercq, O.; Li, J.; Schmidt-Arras, D.; Morales, M. A.; Notredame, C.; Romo, D.; Bastin, P.; Späth, G. F. PLoS Negl. Trop. Dis. 2010, 4, e729. Link
PATENTS
Agelastatin A Derivatives as Anticancer Agents
Daniel Romo, Kevin Shuford, Haoran Xue, Emvia Calixte, Kenneth Hull, Morgan Jouanneau “Synthesis of agelastatin A derivatives as anticancer agents” PCT Int. Appl. Nov. 17, 2022 WO 2022240982 A1.
Pateamine A Derivatives: Translation Inhibitors
Daniel Romo, Omar Robles, Mingzhao Zhu, Kenneth G. Hull “Beta-amino Pateamine A Derivatives for Treating Chronic Lymphocytic Leukemia” PCT Int. Appl. October 5, 2017 WO 2017173313 A1.
Daniel Romo, Omar Robles, Mingzhao Zhu, Kenneth G. Hull “Alpha-amino Pateamine A Derivatives for Treating Chronic Lymphocytic Leukemia” PCT Int. Appl. October 6, 2016 WO 2016161168 A1.
Daniel Romo, Nam Song Choi “Potent Immunosuppressive, Derivatives and Uses” September 2014 Patent # US8841285 B2
Daniel Romo, Nam Song Choi “Potent, Simplified Derivatives of Pateamine A” June 2007 Patent # US7230021; Also issued in Switzerland, France, Germany and the United Kingdom April 2012
Nam Song Choi, Jun O Liu, Woon-Kai Low, Zonggao Shi, Yongjun Dang, Tilman Schneider-Poetsch, Daniel Romo “Anticancer agents and use” Patent # US7737134 June 2010
Belactosin-Orlistat Hybrids as Dual Inhibitors of the Proteasome/FAS
Daniel Romo, Sung Wook Cho “Novel Belactosin Derivatives as Therapeutic Agents/Biological Probes and Their Synthesis” February 2012 Patent # US11/775154
Determination of Marinobufagenin: Assay Development
Jules B. Puschett, Daniel Romo, Luc R. Berghman, Daad Ali Abi-Ghanem, Xinzhong Lai, Method for Determination of Marinobufagenin Levels and Compounds Employable in Such Method U.S. Patent Issued August 2011 Patent # US 2011/0207154 A1.